is a type of hormone that controls or induces a number of physiological reactions and conditions such as narcolepsy
, a sleep disorder where people will fall asleep periodically during the day and also experience paralyzing musculo-skeletal contractions. Actelion, a Swiss drug company is making public a new drug called Almorexant's, its main, active ingredient, orexin-RA-1, can block the orexin system. Studies with rats have shown they slept more soundly and performed better in maze tests the following day suggesting that the drug improves memory capacity. Measurements of muscle tone and brain activity increased in the dream phase of sleep. The dream phase of sleep is when memory is hardwired to the brain. Older sleep medications reduced REM sleep causing people to still feel tired during the day even after a full night of rest. Almorexant also has potential for regulating appetite as it reduces cravings for food.
This new sleep aide is undergoing stage trials and could be available on the market as early as 2012. Unlike other prescription sleep aides, orexin-RA-1 shows no signs of addiction or loss of effectiveness over time. However, the stage trials will determine unwanted side effects since existing sleep medications have a number of side effects. Other tests are being conducted to analyze the drugs effect on the brain and how it can provide other benefits without causing harm to internal systems.
As of March 2010, the first phase III studies were completed with positive results and the drug was well tolerated. However there is an ongoing non-pivotal program, certain safety observations were made that will require further evaluation and assessment in longer-term. Additional studies are being planned to further establish the clinical profile of Almorexant. They will explore aspects of sleep quality, absence of addiction and improved next-day performance. According to Actelion's website the amorexant development program was recently discussed at a meeting with the US Food and Drug Administration.
When side effects cause more harm than good doctors and therapists advise alternative non-medical solutions for those suffering from insomnia. There are herbal supplements that might work just as well without addiction or side effects. Herbal supplements like Melatonin work, it just takes longer to feel the effects. Combining an herbal supplement with other lifestyle changes can improve one’s sleep. Cutting down on caffeine, alcohol and large meals before bedtime is a plus. Avoid stimulating activities such as video games, action movies and exercise. Although light yoga stretches before bedtime encourage calmness and prepare the body for sleep.
Make sure your bedroom is dark, quiet, cool, cozy and preferably pet free. Keep your bedroom a haven for sleep and sex only. Doing your work, reading and watching television in bed will only keep you up longer. Adults need at least 7-8 hours of sleep to feel well-rested the next day.
If you have a severe case of sleep deprivation it is advised to consult with your doctor as he may recommend a sleep specialist or psychiatric professional for additional testing to determine the cause. In any case you need to ask your doctor before taking any herbal supplement or over-the-counter medication as some may interfere with other medications or health issues. Using OTC sleep medications without proper consultation could lead to abuse or overdose.
Fortunately, researchers are working on new prescription sleep aides like Almorexant that will help those with insomnia be able to get the sleep they need without the worries associated with other drugs or over-the-counter medications.
Good Evening,
Rose Sheepskill
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